Biological and clinical perspectives of Nanobiotechnology


  • Rizwana Yasmeen Department of Biological Sciences, University of Sialkot, Pakistan


Nanotechnology is the use of tools at the nano-level (less than 1 micrometer). Nanotechnology is an emerging technique of biotechnology for future generations. Applications of nanotechnology as nanomedicine is used for therapeutic and diagnosis purpose in medical science with imaging techniques in in-vivo and in-vitro. Nanotechnology has applications to treat neurodegenerative disorders such a Parkinson's disease and Alzheimer's disease. It also deals with CNS disorders by drug delivery and gene delivery mechanisms. Nanotechnology tools used for applications are metallic, organic, or inorganic depending on the condition and their nature. Besides these, nanorobotics is an advanced and major application of nanotechnology in diagnosis and treating disorders by interacting, sensing, and manipulating the body. This field has a major scope for future generations to deal with. Nanotechnology does have limitations besides its advantages as there are certain hurdles to cope with. Nanotechnology is a future saver for newcomers and will continue to be efficient to improve human health and the environment.


Taniguchi N (1974) International Conference on Precision Engineering, Part II, Japan Society of Precision Engineering, Tokyo, Japan.

Sarkar, S., & Sarkar, S. C. (2019). Chapter-4 Application of Nanotechnology in

Medicine. MED CAL SCIENCES, 117, 49.

A Joanitti, G., & P Silva, L. (2014). T he emerging potential of by-products as platforms for drug delivery systems. Current drug targets, 15(5), 478-485.

Wang, T., Wang, D., Liu, J., Feng, B., Zhou, F., Zhang, H., .. & Yu, H.(2017). Acidity­

triggered lig and -prese nting nanoparticles to overcome sequential drug delivery barriers to tumors. Nano letters, 17(9), 5429-5436.

Freitas Jr, R. A. (2005). What is nanomedicine?. Nanomedicine: Nanotechnology, Biology and Medicine, 1(1), 2-9.

Zottel, A., Videtic Paska, A., & Jovcevska, I. (2019). anotechnology meets oncology: nanomaterials in brain cancer research, diagnosis and therapy. Materials, 12(10), 1588.


Abdussalam-Mohammed, W. (2019 ). Review of Therapeutic Applications of Nanotechnology in Medicine Field and its Side Effects. Jo urnal of Chemical Reviews, 1(3. pp. 154 - 251) , 243-251.

Flachenecker, P. 2006. Epidemiology of neuroimmunological diseases. J. Neural. 253:

- 8 .

BoverhofDR, Bramante CM, Butala JH, Clancy SF, Lafranconi M, WesU, Gordon SC, Regul. Toxicol. Pharmacol, 73 (2015) [37- 150. [P ubMe d: 26111 608]

McArthur, J.C. 2004. HIV dementia: An evolving disease. J. Neuroimmunol. 157: 3- W.

El-Far, AR. Thymoquinone anticancer discovery: Possi ble mechanisms. Curr. Drug Dis co v. Technol. 2015, 1 2 , 80-89.

Pekmezci M, Perry A. Neuropathology of brain metastases. Surg Neurol In t. 2013; 4:S245 55.

Al-Shamy G, Sawaya R. Management of brain meta stases: the indispensabile role of surge ry. J Neurooncol. 2009; 91: 275- 282.

Chiu YL, Rana TM. 2003. siR A function in R Ai: a chemical modification analysis. RNA. 9:1034 - 1048 20. Stamatoiu 0, Mirzaei J, Feng X, Hegmann T. 2012. Nanoparticles in liquid crystals and liquid crystalline nanoparticles In: Liquid Crystals. Springer, 331- 393.

Baccelli, I., et al. Ide ntifi cation of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat. Biotechnol. 31(6):539 - 544 , 2013.

Kaul G, Amiji M. 2005. Cellular interactions and in vitro DNA transfection studies with poly (ethy le ne g l yco l)-mod ified gelatin nanoparticles.

Rosa N, Simoes R, Magalhaes FD, Marques AT. From mechanical stimulus to bone formation: A review. Med Eng Phys 2015; 37(8): 7 [9-28.

Venkatesan J, Bhatnagar!, Manivasagan P, Kang KH, Kim SK. Alginate composites for bone tis sue engineering: a review. Int J Biol Macromol 2015; 72: 269-81.

Musee, N. (201 I ) . Nanowastes and the environment Potential new waste mana gement paradigm. Environment international, 37(1 ), I I 2-1 28.

Klaine, S. J., Alvarez, P.J. J., Batley, G. E., Fernandes, T. F., Handy, R. D., Lyon, D. Y., &Mahendra, S. (2012). McLauglllin MJ, Lead JR. 2008. Nanomaterials in the environment: Behavior, fate, bioavailability, and effects. Environ Toxicol Chem 27: 1825- 18 51.

Mishra, B. B. T. S., Patel, B. B., & Tiwari, S. (2010). Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery. Nanomedicine: Nanotechnology, biology and medicine, 6(1), 9-24.

Dobrovolskaia, M.A., Shurin, M., &Shvedova, A. A. (2016). Current understanding of interactions between nanoparticles and the immune system. Toxicology and applied pharmacology, 299,78-89.

Meena, N. S., Sahni, Y. P., Thakur, D., & Singh, R. P. (2018). Applications of nano techno logy in veterinary therapeu6cs. J EntomolZool Stud, 6(2), I 67-17 5.

Elgqvist, J. (20 I 7). Nanoparticles as theranostic vehicles in experimental and clinical applic at io ns- focus on prostate and breast cancer. International journal of molecular sciences, 18(5), I 102.

Dos Santos, C. A., Seckler, M. M., Ingle, A. P., Gupta, I., Galdiero, S., Galdiero, M., ... & Rai, M. (2014 ). Silver nanoparticles: therapeutical uses, toxicity, and safety issues. Journal of pharmaceutical sciences, 103(7), 1931- 1 944.

Inga vie GC, Leach JK, Castano 0, Planell JA, Ingavle GC, Leach JK. Advancements in e lec trospinning of polymeric nano fibro us scaffolds for tissue engineering. Tissue Eng Part B Rev 2014 ; 20(4): 277-93.

Liberman, A., Mendez, N., Trogler, W. C., & Kummel, A. C.(2014). Synthesis and surface functionalization of silica nanoparticles for nanomedicine. Surface science reports, 69(2-3), 132-158



How to Cite

Yasmeen, R. (2021). Biological and clinical perspectives of Nanobiotechnology. Research Journal in Advanced Sciences, 2(2), 1-8. Retrieved from