It’s all in the noise: A review of noise stress on gastric secretions via the stimulation of corticosteroids and management options


Ravinder Mehra
Sumel Ashique
Afzal Hussain
Mohammad A. Altamimi
Mahesh Prashad
Thomas J. Webster


One of the toughest sources of restrictions on the environment and the workplace is noise. Numerous impacts of noise on the immune system, hormone levels, and the cardiovascular and pulmonary systems have been well recognized. In this regard, noise induced stress imparts a very serious effect on the body and is considered one of the richest elements of pollution in the environment. It is well documented in the research arena that noise affects immune function, hormonal levels, and the cardiovascular and respiratory systems through the secretion of hormones and other biomolecules. For example, the excessive secretion of acids leads to an acidic bounce or the peptic juice over secretion that can end with gastric as well as the peptic ulcers. This review article was focused on the latest information concerning gastric acid secretion through noise induced corticosteroid hormones. The pathophysiology of noise stress-induced disorders is heavily influenced by the disruption of the brain-gut axis. Noise stress enhances visceral sensitivity, affects gastrointestinal (GI) motility, increases intestinal permeability, and profoundly activates mast cells, which release a variety of proinflammatory mediators. The main aim here is to make clear that the effects of noise of varying intensities can alter gastric stimulation and key health issues so that the medical community can focus on probable treatment options, something that has not been acknowledged in medicine to date.




How to Cite
It’s all in the noise: A review of noise stress on gastric secretions via the stimulation of corticosteroids and management options. (2022). Research Journal in Medical and Health Sciences, 3(1), 40-56.

How to Cite

It’s all in the noise: A review of noise stress on gastric secretions via the stimulation of corticosteroids and management options. (2022). Research Journal in Medical and Health Sciences, 3(1), 40-56.


Muzet, A. (2007). Environmental noise, sleep and health. Sleep medicine reviews, 11(2), 135-142.

Basner, M., Babisch, W., Davis, A., Brink, M., Clark, C., Janssen, S., & Stansfeld, S. (2014). Auditory and non-auditory effects of noise on health. The lancet, 383(9925), 1325-1332.

Sim, C. S., Sung, J. H., Cheon, S. H., Lee, J. M., Lee, J. W., & Lee, J. (2015). The effects of different noise types on heart rate variability in men. Yonsei medical journal, 56(1), 235-243.

Stansfeld, S. A., & Matheson, M. P. (2003). Noise pollution: non-auditory effects on health. British medical bulletin, 68(1), 243-257.

Leventhall, H. G. (2004). Low frequency noise and annoyance. Noise and Health, 6(23), 59.

Tomei, F., Papaleo, B., Baccolo, T. P., Persechino, B., Spanò, G., & Rosati, M. V. (1994). Noise and gastric secretion. American Journal of Industrial Medicine, 26(3), 367-372.

Hsu, T. et al. (1994) Journal of clinical outcomes management : JCOM., Journal of Clinical Outcomes Management. Turner White Communications. Available at: (Accessed: 25 Dec 2020)

Babisch, W. (2002). The noise/stress concept, risk assessment and research needs. Noise and health, 4(16), 1.

Brown, C. H. (1963). Acute emotional crises and ulcerative colitis. The American journal of digestive diseases, 8(6), 525-536.

Chrousos, G. P., & Gold, P. W. (1992). The concepts of stress and stress system disorders: overview of physical and behavioral homeostasis. Jama, 267(9), 1244-1252.

Carrasco, G. A., & Van de Kar, L. D. (2003). Neuroendocrine pharmacology of stress. European journal of pharmacology, 463(1-3), 235-272.

Goyal, R. K., & Hirano, I. (1996). The enteric nervous system. New England Journal of Medicine, 334(17), 1106-1115.

Locatelli, V., Bresciani, E., Tamiazzo, L., & Torsello, A. (2010). Central nervous system-acting drugs influencing hypothalamic-pituitary-adrenal axis function. Pediatric Neuroendocrinology, 17, 108-120.

Burton, J. L., Madsen, S. A., Chang, L. C., Weber, P. S., Buckham, K. R., van Dorp, R., ... & Earley, B. (2005). Gene expression signatures in neutrophils exposed to glucocorticoids: A new paradigm to help explain “neutrophil dysfunction” in parturient dairy cows. Veterinary immunology and immunopathology, 105(3-4), 197-219.

Spies, C. M., Strehl, C., van der Goes, M. C., Bijlsma, J. W., & Buttgereit, F. (2011). Glucocorticoids. Best Practice & Research Clinical Rheumatology, 25(6), 891-900.

Strehl, C., Ehlers, L., Gaber, T., & Buttgereit, F. (2019). Glucocorticoids—All-Rounders tackling the versatile players of the immune system. Frontiers in immunology, 10, 1744.

Ciriaco, M. et al. (2013) ‘Corticosteroid-related central nervous system side effects’, J. Pharmacol. Pharmacotherapy. 4(5), 94

Hackney, A. C. (2017). Doping, performance-enhancing drugs, and hormones in sport: mechanisms of action and methods of detection. Elsevier.

Nadolnik, L. (2012). Role of glucocorticoids in regulation of iodine metabolism in thyroid gland: effects of hyper-and hypocorticism. Glucocorticoids-New Recognition of Our Familiar Friend.

Patton, G. C., & Viner, R. (2007). Pubertal transitions in health. The lancet, 369(9567), 1130-1139.

De Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998). Brain corticosteroid receptor balance in health and disease. Endocrine reviews, 19(3), 269-301.

Hardy, R. S., Raza, K., & Cooper, M. S. (2012). Endogenous glucocorticoids in inflammation: contributions of systemic and local responses. Swiss medical weekly, (31).

Quartieri, J., Mastorakis, N. E., Iannone, G., Guarnaccia, C., D’ambrosio, S., Troisi, A., & Lenza, T. L. L. (2009, December). A review of traffic noise predictive models. In Recent Advances in Applied and Theoretical Mechanics, 5th WSEAS International Conference on Applied and Theoretical Mechanics (MECHANICS’09) Puerto De La Cruz, Tenerife, Canary Islands, Spain December (pp. 14-16).

Smith, S. M., & Vale, W. W. (2022). The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues in clinical neuroscience.

Kim, A., Sung, J. H., Bang, J. H., Cho, S. W., Lee, J., & Sim, C. S. (2017). Effects of self-reported sensitivity and road-traffic noise levels on the immune system. PloS one, 12(10), e0187084.

Pouryaghoub, G., Mehrdad, R., & Valipouri, A. (2016). Effect of acute noise exposure on salivary cortisol: a randomized controlled trial. Acta Medica Iranica, 657-661.

Cantuaria, M. L., Usemann, J., Proietti, E., Blanes-Vidal, V., Dick, B., Flück, C. E., ... & BILD study group. (2018). Glucocorticoid metabolites in newborns: a marker for traffic noise related stress?. Environment international, 117, 319-326.

Kim, C. Y., Ryu, J. S., & Hong, S. S. (1968). Effect of air-craft noise on gastric function. Yonsei medical journal, 9(2), 149-154.

Caboclo, J. L. F., de Assis Cury, F., Borin, A. A., Caboclo, L. O. S. F., Ribeiro, M. F. S. C., de Freitas, P. J., ... & Andersson, S. (2009). Gastric secretion elicited by conditioning in rats. Scandinavian journal of gastroenterology, 44(6), 672-679.

Holtmann, G., Kriebel, R., & Singer, M. V. (1990). Mental stress and gastric acid secretion. Digestive diseases and sciences, 35(8), 998-1007.

Bhatia, V., & Tandon, R. K. (2005). Stress and the gastrointestinal tract. Journal of gastroenterology and hepatology, 20(3), 332-339.

Soderholm, J. D., & Perdue, M. H. (2001). II. Stress and intestinal barrier function. American Journal of Physiology-Gastrointestinal and Liver Physiology, 280(1), G7-G13.

Nakade, Y., Fukuda, H., Iwa, M., Tsukamoto, K., Yanagi, H., Yamamura, T., ... & Takahashi, T. (2007). Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(4), G1037-G1044.

Moslehi, A., Nabavizadeh, R. F., Keshavarz, M., Rouhbakhsh, N., Sotudeh, M., & Salimi, E. (2010). Traffic noise exposure increases gastric acid secretion in rat.

Cui, B., Gai, Z., She, X., Wang, R., & Xi, Z. (2016). Effects of chronic noise on glucose metabolism and gut microbiota–host inflammatory homeostasis in rats. Scientific reports, 6(1), 1-8.

Agrawal, A., Jaggi, A. S., & Singh, N. (2011). Pharmacological investigations on adaptation in rats subjected to cold water immersion stress. Physiology & behavior, 103(3-4), 321-329.

Caixeta, D. C., Teixeira, R. R., Peixoto, L. G., Machado, H. L., Baptista, N. B., de Souza, A. V., ... & Salmen Espindola, F. (2018). Adaptogenic potential of royal jelly in liver of rats exposed to chronic stress. PloS one, 13(1), e0191889.

Konturek, S. J., Konturek, J. W., Pawlik, T., & Brzozowski, T. (2004). Brain-gut axis and its role in the control of food intake. Journal of physiology and pharmacology: an official journal of the Polish Physiological Society, 55(1 Pt 2), 137-154.

Laranjeira, C., & Pachnis, V. (2009). Enteric nervous system development: Recent progress and future challenges. Autonomic Neuroscience, 151(1), 61-69.

Taché, Y., & Bonaz, B. (2007). Corticotropin-releasing factor receptors and stress-related alterations of gut motor function. The Journal of clinical investigation, 117(1), 33-40.

Stasi, C., & Orlandelli, E. (2008). Role of the brain-gut axis in the pathophysiology of Crohn’s disease. Digestive diseases, 26(2), 156-166.

Zareie, M., Johnson-Henry, K., Jury, J., Yang, P. C., Ngan, B. Y., McKay, D. M., ... & Sherman, P. M. (2006). Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress. Gut, 55(11), 1553-1560.

Lee, H. S., Noh, C. K., & Lee, K. J. (2017). The effect of acute stress on esophageal motility and gastroesophageal reflux in healthy humans. Journal of Neurogastroenterology and Motility, 23(1), 72.

Li, J., Brackbill, R. M., Stellman, S. D., Farfel, M. R., Miller-Archie, S. A., Friedman, S., ... & Cone, J. (2011). Gastroesophageal reflux symptoms and comorbid asthma and posttraumatic stress disorder following the 9/11 terrorist attacks on World Trade Center in New York City. Official journal of the American College of Gastroenterology| ACG, 106(11), 1933-1941.

Perlman, S. E., Friedman, S., Galea, S., Nair, H. P., Erős-Sarnyai, M., Stellman, S. D., ... & Greene, C. M. (2011). Short-term and medium-term health effects of 9/11. The Lancet, 378(9794), 925-934.

Pouderoux, P., Verdier, E., & Kahrilas, P. J. (2003). Patterns of esophageal inhibition during swallowing, pharyngeal stimulation, and transient LES relaxation. American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(2), G242-G247.

Brzozowski, T., Konturek, P. C., Konturek, S. J., Brzozowska, I., & Pawlik, T. (2005). Role of prostaglandins in gastroprotection and gastric adaptation. Journal of physiology and pharmacology: an official journal of the Polish Physiological Society, 56, 33-55.

Ali, T., & Harty, R. F. (2009). Stress-induced ulcer bleeding in critically ill patients. Gastroenterology Clinics, 38(2), 245-265.

Palka, M., Krztoń-Królewiecka, A., Tomasik, T., Seifert, B., Wójtowicz, E., & Windak, A. (2014). Management of gastrointestinal disorders in Central and Eastern Europe: self-reported practice of primary care physicians. Slovenian Journal of Public Health, 53(4), 294.

Bernstein, C. N., Nugent, Z., Longobardi, T., & Blanchard, J. F. (2009). Isotretinoin is not associated with inflammatory bowel disease: a population-based case-control study. Official journal of the American College of Gastroenterology| ACG, 104(11), 2774-2778.

Israeli, E., Hershcovici, T., Berenshtein, E., Zannineli, G., Wengrower, D., Weiss, O., ... & Goldin, E. (2008). The effect of restraint stress on the normal colon and on intestinal inflammation in a model of experimental colitis. Digestive diseases and sciences, 53(1), 88-94.

Bailey, M. T., Dowd, S. E., Galley, J. D., Hufnagle, A. R., Allen, R. G., Lyte, M. (2011). Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain, behavior, and immunity, 25(3), 397-407.

Aihara, T., Nakamura, E., Amagase, K., Tomita, K., Fujishita, T., Furutani, K., Okabe, S. (2003). Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present, and future. Pharmacology & therapeutics, 98(1), 109-127.

Schubert, M. L., & Peura, D. A. (2008). Control of gastric acid secretion in health and disease. Gastroenterology, 134(7), 1842-1860.

Parsons, M. E., & Ganellin, C. R. (2006). Histamine and its receptors. British journal of pharmacology, 147(S1), S127-S135.

Sachs, G., Shin, J. M., Howden, C. W. (2006). The clinical pharmacology of proton pump inhibitors. Alimentary pharmacology & therapeutics, 23, 2-8.

Fock, K. M., Ang, T. L., Bee, L. C., Lee, E. J. D. (2008). Proton pump inhibitors. Clinical pharmacokinetics, 47(1), 1-6.

Castle, J. S., Xing, J. H., Warner, M. R., Korsten, M. A. (2007). Environmental noise alters gastric myoelectrical activity: Effect of age. World Journal of Gastroenterology: WJG, 13(3), 403.

Mu, Z. B., Huang, Y. X., Zhao, B. M., Liu, Z. X., Zhang, B. H., Wang, Q. L. (2006). Effect of explosive noise on gastrointestinal transit and plasma levels of polypeptide hormones. World Journal of Gastroenterology: WJG, 12(14), 2284.

Min, J. Y., & Min, K. B. (2018). Cumulative exposure to nighttime environmental noise and the incidence of peptic ulcer. Environment international, 121, 1172-1178.

Chi, H., Cao, W., Zhang, M., Su, D., Yang, H., Li, Z., Li, C., She, X., Wang, K., Gao, X., Ma, K., Zheng, P., Li, X., Cui, B. (2021). Environmental noise stress disturbs commensal microbiota homeostasis and induces oxi-inflammmation and AD-like neuropathology through epithelial barrier disruption in the EOAD mouse model. Journal of Neuroinflammation, 18(1), 1-16.

Chang, J. Y., Talley, N. J. (2010). Current and emerging therapies in irritable bowel syndrome: from pathophysiology to treatment. Trends in pharmacological sciences, 31(7), 326-334.

Sachs, G. (2003). Physiology of the parietal cell and therapeutic implications. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 23(10P2), 68S-73S.

Flockhart, D. A., Desta, Z., Mahal, S. K. (2000). Selection of drugs to treat gastro-oesophageal reflux disease. Clinical pharmacokinetics, 39(4), 295-309.

Konturek, P. C., Brzozowski, T., Konturek, S. J. (2011). Gut clock: implication of circadian rhythms in the gastrointestinal tract. J Physiol Pharmacol, 62(2), 139-150.

Bleser, S. (2011). Alosetron for severe diarrhea-predominant irritable bowel syndrome: improving patient outcomes. Current medical research and opinion, 27(3), 503-512.

Pimentel, M., Lembo, A., Chey, W. D., Zakko, S., Ringel, Y., Yu, J., ... & Forbes, W. P. (2011). Rifaximin therapy for patients with irritable bowel syndrome without constipation. New england journal of medicine, 364(1), 22-32.

Keller, J., van der Voort, I., Pehl, C., Nicolaus, M., Schirra, J., Fox, M., ... & Storr, M. (2009). Performance and interpretation of esophageal manometry: recommendations of the German Societies for Neurogastroenterology and Motility (DGNM), for Digestive and Metabolic Diseases (DGVS) and for General and Visceral Surgery (DGAV). Zeitschrift fur Gastroenterologie, 47(9), 830-845.

Chey, W. D., Maneerattaporn, M., & Saad, R. (2011). Pharmacologic and complementary and alternative medicine therapies for irritable bowel syndrome. Gut and liver, 5(3), 253.

Awad, R. A., & Camacho, S. (2010). A randomized, double‐blind, placebo‐controlled trial of polyethylene glycol effects on fasting and postprandial rectal sensitivity and symptoms in hypersensitive constipation‐predominant irritable bowel syndrome. Colorectal Disease, 12(11), 1131-1138.

Manabe, N., Rao, A. S., Wong, B. S., & Camilleri, M. (2010). Emerging pharmacologic therapies for irritable bowel syndrome. Current gastroenterology reports, 12(5), 408-416.

Camilleri, M. (2010). New receptor targets for medical therapy in irritable bowel syndrome. Alimentary pharmacology & therapeutics, 31(1), 35-46.

Rahimi, R., Nikfar, S., Rezaie, A., & Abdollahi, M. (2009). Efficacy of tricyclic antidepressants in irritable bowel syndrome: a meta-analysis. World journal of gastroenterology: WJG, 15(13), 1548.

Ries, R. K., Gilbert, D. A., & Katon, W. (1984). Tricyclic antidepressant therapy for peptic ulcer disease. Archives of internal medicine, 144(3), 566-569.

Elliott, S. N., Wallace, J. L., McKnight, W., Gall, D. G., Hardin, J. A., Olson, M., & Buret, A. (2000). Bacterial colonization and healing of gastric ulcers: the effects of epidermal growth factor. American Journal of Physiology-Gastrointestinal and Liver Physiology, 278(1), G105-G112.

Whelan, K. (2011). Probiotics and prebiotics in the management of irritable bowel syndrome: a review of recent clinical trials and systematic reviews. Current Opinion in Clinical Nutrition & Metabolic Care, 14(6), 581-587.

Trop, T. K. (2014). Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease. World journal of gastroenterology: WJG, 20(33), 11505.

Khoder, G., Al‑Menhali, A. A., Al‑Yassir, F., & Karam, S. M. (2016). Potential role of probiotics in the management of gastric ulcer. Experimental and therapeutic medicine, 12(1), 3-17.

Virchenko, O. V., Falalyeyeva, T. M., Beregova, T. V., & Maryana, S. Y. (2015). The multistrain probiotic enhances the healing process of stress-induced lesions of the gastric mucosa of rats. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 6(1), 249-259.

Shane, A. L., Cabana, M. D., Ellis, C. L., Heimbach, J. T., Hempel, S., Hummelen, R., ... & Vidry, S. (2010). Guide to designing, conducting, publishing, and communicating results of clinical studies involving probiotic applications in human participants. Gut Microbes, 1(4), 243-253.

Cano-Garrido, O., Seras-Franzoso, J., & Garcia-Fruitós, E. (2015). Lactic acid bacteria: reviewing the potential of a promising delivery live vector for biomedical purposes. Microbial cell factories, 14(1), 1-12.

Mohamadzadeh, M., & Owen, J. L. (2011). Reprogramming intestinal immunity is the answer to induced pathogenic inflammation. Immunotherapy, 3(12), 1415-1417.

Bermúdez-Humarán, L. G. (2009). Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins. Human vaccines, 5(4), 264-267.

Marelli, B., Perez, A. R., Banchio, C., de Mendoza, D., & Magni, C. (2011). Oral immunization with live Lactococcus lactis expressing rotavirus VP8* subunit induces specific immune response in mice. Journal of Virological Methods, 175(1), 28-37.

Hill, C., Guarner, F., Reid, G., Gibson, G. R., Merenstein, D. J., Pot, B., ... & Sanders, M. E. (2014). Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature reviews Gastroenterology & hepatology.