Evaluation of ulcer-protective effect of the ethanolic extract of Bryophyllum pinnatum leaves on ethanol-induced ulcer

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Published: Oct 27, 2020
DOI: https://doi.org/10.58256/rjmhs.v1i1.269

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Augustine Madueke
university of Nigeria, Nsukka, Nigeria
Asumpta Anosike
University of Nigeria Nsukka
Valentine Nwanelo
University of Nigeria Nsukka
Benjamin Amadi
University of Nigeria Nsukka

Abstract

Bryophyllum pinnatum extract has been employed for different pharmacological uses ranging from antimicrobial activity, anti-inflammatory, antidiabetic, anticonvulsant, antihypertensive and anticancer activity, antitumuour, anthelmentic, hepatoprotective, antinociceptive, nephroprotective, antioxidant activity, analgesic, anticonvulsant, neuropharmacological, antipyretic, haemostatic and wound healing properties. However, the use of ethanolic extract of B. pinnatum leaves (EEBPL) in the management of ulcer not known. The phytochemical analyses, acute toxicity studies and ulcer studies of ethanolic extract of B. pinnatum leaves was carried out using standard methods. Bryophyllum pinnatum leaves extract contains flavonoids, tannins, terpenoids, alkaloids, reducing sugars, phenols and carbohydrates. Acute toxicity study revealed that EEBPL was not toxic at all doses studied. Ulcer protective studies demonstrated ulcer-protective activity of EEBPL which compared favorably with the standard drug (omeprazole). We hereby submit that EEBPL is safe regarding toxicity in ulcer protection and could be used in anti-ulcer formulations.

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How to Cite
Madueke, A., Anosike, A., Nwanelo, V., & Amadi, B. (2020). Evaluation of ulcer-protective effect of the ethanolic extract of Bryophyllum pinnatum leaves on ethanol-induced ulcer. Research Journal in Medical and Health Sciences, 1(1). https://doi.org/10.58256/rjmhs.v1i1.269
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Vol. 1 No. 1 (2020)
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Author Biographies

Asumpta Anosike, University of Nigeria Nsukka

Anosike Chioma Asumpta is a senior lecturer in the department of biochemistry, university of Nigeria Nsukka. She is a researcher with several publications in both local and international journals. She is also a reviewer and has several undergraduate and postgraduate students supervised over the years. Her research areas include pharmacological biochemistry, nutritional biochemistry and drug delivery.

Valentine Nwanelo, University of Nigeria Nsukka

Nwanelo Valentine Odirachukwumma is a postgraduate student and a graduate assistant in the department of biochemistry, university of Nigeria, Nsukka. His research interest is in pharmacological biochemistry. He is a young researcher, passionate about unraveling pharmacological basis of drug discovery.

Benjamin Amadi, University of Nigeria Nsukka

Amadi Benjamin is a postgraduate student of biochemistry, university of Nigeria, Nsukka. His research interest is in nutritional biochemistry and medical biochemistry. He is a young researcher, passionate about unraveling the nutritional basis of disease management.

How to Cite

Madueke, A., Anosike, A., Nwanelo, V., & Amadi, B. (2020). Evaluation of ulcer-protective effect of the ethanolic extract of Bryophyllum pinnatum leaves on ethanol-induced ulcer. Research Journal in Medical and Health Sciences, 1(1). https://doi.org/10.58256/rjmhs.v1i1.269
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