Periodontal disease: Understanding oral-systemic connections


  • Sarita Kumari Yadav Department of Pharmacy, Moti Lal Nehru Medical College, Allahabad-211002, India
  • Brahmeshwar Mishra Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Varanasi-221005, India
  • Nalini Kanta Sahoo Marri Laxman Reddy Institute of Pharmacy,Dundigal,Medchal,Telangana,India,500043


bacteremia, inflammation, metastatic spread, periodontal ligaments


Periodontal diseases are collection of several pathological conditions characterized by degeneration of gums, periodontal ligaments, alveolar bone, dental cementum, and migration of epithelium leading to the formation of periodontal pockets. Metastatic spread, metastatic injury, and metastatic inflammation are the three basic pathways linking oral infections to secondary systemic diseases. Metastatic spread of infection may occur from oral cavity to systemic circulation due to transient bacteremia. The study emphasizes on discussion about potential risk factors. Therefore, it is important to understand all possible risk-factors if morbidity and mortality due to this disease are to be reduced. Oral infection may represent a significant risk factor for systemic diseases, and hence the control of oral disease is essential for the prevention and management of these systemic conditions.


Armitage, G.C., 1999. Development of a classification system for periodontal diseases and conditions. Annals of periodontology 4, 1-6.

Caton, J., Ryan, M.E., 2011. Clinical studies on the management of periodontal diseases utilizing subantimicrobial dose doxycycline (SDD). Pharmacological research 63, 114-120.

Cotti, E., Dessì, C., Piras, A., Mercuro, G., 2011. Can a chronic dental infection be considered a cause of cardiovascular disease? A review of the literature. International journal of cardiology 148, 4-10.

Craig, R.G., Spittle, M.A., Levin, N.W., 2002. Importance of periodontal disease in the kidney patient. Blood purification 20, 113-119.

Drangsholt, M., 1992. Association of dental procedures and infective endocarditis: a meta-analysis. University of Washington.

Havemose-Poulsen, A., Holmstrup, P., 1997. Factors affecting IL-1-mediated collagen metabolism by fibroblasts and the pathogenesis of periodontal disease: a review of the literature. Critical Reviews in Oral Biology & Medicine 8, 217-236.

Katz, J., Chaushu, G., Sharabi, Y., 2001. On the association between hypercholesterolemia, cardiovascular disease and severe periodontal disease. Journal of clinical periodontology 28, 865-868.

Kirkwood, K.L., Rossa Jr, C., 2009. The potential of p38 MAPK inhibitors to modulate periodontal infections. Current drug metabolism 10, 55-67.

Kuo, L.-C., Polson, A.M., Kang, T., 2008. Associations between periodontal diseases and systemic diseases: a review of the inter-relationships and interactions with diabetes, respiratory diseases, cardiovascular diseases and osteoporosis. Public health 122, 417-433.

Li, X., Kolltveit, K.M., Tronstad, L., Olsen, I., 2000. Systemic diseases caused by oral infection. Clinical microbiology reviews 13, 547-558.

Mishra, B., Yadav, S., 2015. Periodontal Diseases and Perioceutics. Austin therapeutics 2, 1-2.

Oh, T.J., Eber, R., Wang, H.L., 2002. Periodontal diseases in the child and adolescent. Journal of clinical periodontology 29, 400-410.

Page, R.C., 1998. The pathobiology of periodontal diseases may affect systemic diseases: inversion of a paradigm. Annals of periodontology 3, 108-120.

Pihlstrom, B.L., Michalowicz, B.S., Johnson, N.W., 2005. Periodontal diseases. The Lancet 366, 1809-1820.

Pischon, N., Heng, N., Bernimoulin, J.-P., Kleber, B.-M., Willich, S., Pischon, T., 2007. Obesity, inflammation, and periodontal disease. Journal of dental research 86, 400-409.

Ryan, M.E., 2002. Host modulation: conceptualization to clinical trials and integration into clinical practice. Journal of the California Dental Association 30, 285-288, 290-285.

Seymour, G., Ford, P., Cullinan, M., Leishman, S., Yamazaki, K., 2007. Relationship between periodontal infections and systemic disease. Clinical Microbiology and Infection 13, 3-10.

Shultis, W.A., Weil, E.J., Looker, H.C., Curtis, J.M., Shlossman, M., Genco, R.J., Knowler, W.C., Nelson, R.G., 2007. Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes. Diabetes Care 30, 306-311.

WHO, 2012. World Health Organization: Oral health.



How to Cite

Yadav, S. K., Mishra, B., & Sahoo, N. K. (2020). Periodontal disease: Understanding oral-systemic connections. Journal of Public Health and Sanitation, 1(1), 25. Retrieved from