Journal of Tropical and Infectious Diseases https://royalliteglobal.com/jtid <p style="text-align: justify;"><strong>Journal of Tropical and Infectious Diseases</strong> publishes authoritative and original articles, critical and systematic reviews, editorials, perspectives, short communications, commentaries, book reviews, letters to the editor and Special Issues on all aspects of tropical medicine and tropical infectious diseases. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. <strong>Journal of Tropical and Infectious Diseases</strong> publishes on all tropical diseases of global significance, as well as neglected tropical diseases as defined from time-to-time by the World Health Organization. The scope of the journal includes, but is not limited to: clinical tropical medicine, tropical public health and tropical infectious diseases.</p> en-US ojwang@royalliteglobal.com (Amos Ojwang') royallitepublishers@gmail.com (Geoffrey Okeyo) Tue, 11 Aug 2020 15:02:52 +0000 OJS 3.2.1.1 http://blogs.law.harvard.edu/tech/rss 60 The Formulation and Evaluation of Rasagiline Mesylate Transdermal Patch for Enhanced Topical Delivery https://royalliteglobal.com/jtid/article/view/118 <p><strong>Abstract</strong>:</p> <p>Rasagiline mesylate is an irreversible inhibitor of monoamine oxidase (MAO) used for the treatment of the signs and symptoms of idiopathic Parkinson’s disease as initial monotherapy and as adjunct therapy to levodopa. &nbsp;It is a water soluble molecule that undergoes extensive hepatic first pass metabolism resulting to poor bioavailability. The aim of the present study is to formulate and evaluate transdermal delivery system of Rasagiline mesylate.&nbsp; Patches of transdermal delivery systems were formulated by solvent casting technique using different amount of Eudragit L100 as a matrixing material and PEG400 as plasticizer. During preparation of transdermal patches achieving a good tackiness is a most challenging so different formulations were prepared and optimized for finding good tackiness. Among these formulations F12 and F 21 shows optimum results, these formulations are subjected to diffusion studies by using porcine ear skin (80-90um thick) for 24 hrs As the concentration of polymer (Eudragit) increases the permeation was found to decrease. The average amount of drug diffused from F12 and F21 formulation was found to be 25.09µmoles/sq.cm and 21.45µmols/sq.cm respectively.</p> <p>&nbsp;</p> Sujay Hulyalkar, Shivakumar H N , Archana S. Patil., Rekha Rao Copyright (c) 2020 Journal of Tropical and Infectious Diseases https://royalliteglobal.com/jtid/article/view/118 Tue, 11 Aug 2020 00:00:00 +0000